ClariGen

SKINCARE
·
PRESCRIPTION

ClariGen

Tretinoin
·
Clindamycin 1%
·
Spironolactone 5%

HORMONAL ACNE
TONE
TEXTURE

Three prescription actives. One comprehensive formula. Targets the androgen-driven root of hormonal acne, with antibacterial and retinoid action for breakouts.

Hormonal Regulation: Spironolactone works at the hormonal level, helping curb excess oil production linked to breakouts.
Antibacterial Action: Clindamycin targets acne-causing bacteria, helping prevent new breakouts.
Pore-Clearing Retinoid: Tretinoin works to unclog pores and fade the appearance of post-acne marks over time.

HSA/FSA Eligible
Free Delivery
Manufactured in the USA
Consult & Care Included

30 day supply. Pause, change frequency or cancel at any time.

WHAT HAPPENS NEXT

Check out

Answer a few questions

Doctor reviews & prescribes

Apply a pea-sized amount nightly to clean skin, as tolerated. On ClariGen nights, skip other retinols. Protect your skin daily with SPF.

Compounded medication. Not reviewed by the FDA for safety or effectiveness. Price includes doctor consult fee of $20. Rx required. A licensed provider will review your information and prescribe treatment only if appropriate.

Hormonal acne is rarely just one thing. It’s oil, bacteria, and clogged pores, all at once. ClariGen combines three prescription actives into one formula to address it from multiple angles.

Dr. Maxfield

Co-founder, dermatologist

Every ingredient, intentional

What's in the formula, what it does, and why our physicians chose it.

What's in the formula, what it does,
and why our physicians chose it.

Tretinoin

Widely regarded as the gold standard for both acne and signs of aging. Tretinoin binds directly to retinoid receptors to accelerate cell turnover, decrease oil production, and signal collagen and elastin renewal.

Clindamycin

A prescription antibiotic that targets acne-causing bacteria directly at the source. Works synergistically with retinoids to help reduce inflammatory lesions and lower the risk of antibiotic resistance.

Spironolactone

Blocks the androgen receptors that drive excess oil production and hormonal breakouts. A prescription-only ingredient used off-label to help address hormonal acne at the source.

Ceramide Complex

Lipids that make up approximately 50% of the skin barrier's composition. Replenish the structural integrity of the stratum corneum when prescription actives cause barrier disruption.

How it works

Choose your treatment

Select the treatment that fits your needs and complete checkout. No waiting room, no appointment required.

Answer a few questions

Tell us about your health goals and concerns through a simple, secure questionnaire.

Physician reviews and prescribes

A board-certified physician reviews your intake and issues a prescription if clinically appropriate. You'll approve any changes your doctor suggests before your treatment is confirmed.

Access ongoing support

Message your physician anytime with questions, follow-ups, or to discuss adjustments to your treatment.

Most single-ingredient acne treatments only work one angle. ClariGen combines three actives to cover more ground: Spironolactone helps curb hormonally driven oil production behind breakouts, Clindamycin targets acne-causing bacteria, and Tretinoin helps keep pores clear and fade the look of post-acne marks.

Not quite. ClariGen delivers Spironolactone topically, working locally on the skin with minimal systemic side effects, alongside two other potent actives. Oral Spironolactone is absorbed throughout your body and is typically used for more severe or hormone-driven acne. Sometimes both are prescribed together for more stubborn cases. Ask your provider what makes sense for you.

ClariGen is built specifically for hormonal, bacteria-involved breakouts
ClariFade pairs Tretinoin with Azelaic Acid, better if you’re dealing with redness or dark spots alongside acne
TretPeptide+ pairs Tretinoin with a Peptide Stack, so you get acne care and supercharged anti-aging support together

If your acne is cyclical, cystic, or jawline-focused, ClariGen’s hormonal angle is often the better fit. Not sure? Take our skin quiz for a personalized recommendation, or pick whichever matches your goals. Your physician will confirm the right fit for you during your consult.

Most patients start noticing fewer breakouts within 6 to 8 weeks, with continued improvement over the following months. Mild dryness or irritation from Tretinoin can occur early on. That’s just part of the adjustment period, not a sign it’s not working.

ClariGen shouldn’t be used during pregnancy, and it isn’t recommended while breastfeeding, so let your provider know if either applies, or if you’re trying to conceive. They’ll help you figure out the safest option for your skin right now.

Each bottle is a 30-day supply if used as directed. You can change your delivery frequency, cancel, or pause your prescription anytime.

Your price includes your prescription treatment, physician consultation, and ongoing care, including unlimited messaging with your doctor for questions, follow-ups, or treatment adjustments. You can also adjust your delivery frequency, pause, or cancel anytime.

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ClariGen