TretPeptide+

0.025%

SKINCARE
·
PRESCRIPTION

TretPeptide+

Tretinoin
·
Peptide Stack
·
Niacinamide
·
Sodium Hyaluronate

ACNE
FINE LINES
TEXTURE
TONE

The gold standard of retinoids with next-generation peptide technology for a smarter, supercharged approach to anti-aging and clearer skin.

Prescription-Grade Renewal: Tretinoin accelerates cell turnover to visibly improve the look of texture, fine lines, blemishes, and tone.
Anti-Aging Peptide Stack: Minimizes the appearance of expression lines while supporting collagen and elastin production.
Barrier-First Hydration: Ceramide Complex, Niacinamide 4%, Squalane and more keep your barrier strong and skin hydrated through consistent use.

HSA/FSA Eligible
Free Delivery
Manufactured in the USA
Consult & Care Included

Not sure what strength is right? Your doctor confirms the right strength after your online visit.

WHAT HAPPENS NEXT

1

Check out

2

Answer a few questions

3

Doctor reviews & prescribes

Apply a pea-sized amount (about two pumps) nightly to clean skin, as tolerated. On TretPeptide+ nights, skip other retinols. Protect your skin daily with SPF.

Compounded medication. Not reviewed by the FDA for safety or effectiveness. Price includes doctor consult fee of $20. Rx required. A licensed provider will review your information and prescribe treatment only if appropriate.

TretPeptide+ a formula I was personally passionate about bringing to life. Prescription tretinoin, supercharged with our Peptide Stack, and built for daily comfort.

Dr. Maxfield

Co-founder, dermatologist

Every ingredient, intentional

What's in the formula, what it does, and why our physicians chose it.

What's in the formula, what it does,
and why our physicians chose it.

Tretinoin

Widely regarded as the gold standard for both acne and signs of aging. Tretinoin binds directly to retinoid receptors to accelerate cell turnover, decrease oil production, and signal collagen and elastin renewal.

Niacinamide

By decreasing melanin transfer, reducing oil production, and minimizing transepidermal water loss, Niacinamide (Vitamin B3) works to even skin tone, control shine, and reinforce the skin barrier.

Sodium Hyaluronate

A low-molecular-weight form of hyaluronic acid that penetrates deeper into the skin than standard hyaluronic acid. Binds up to 1,000 times its weight in water to maintain hydration at the cellular level.

Peptide Stack

A duo of powerful peptides that work together at the surface and below to visibly soften fine lines and support firmer, smoother-looking skin.

Ceramide Complex

Lipids that make up approximately 50% of the skin barrier's composition. Replenish the structural integrity of the stratum corneum when prescription actives cause barrier disruption.

How it works

Choose your treatment

Select the treatment that fits your needs and complete checkout. No waiting room, no appointment required.

Answer a few questions

Tell us about your health goals and concerns through a simple, secure questionnaire.

Physician reviews and prescribes

A board-certified physician reviews your intake and issues a prescription if clinically appropriate. You'll approve any changes your doctor suggests before your treatment is confirmed.

Access ongoing support

Message your physician anytime with questions, follow-ups, or to discuss adjustments to your treatment.

FAQ

TretPeptide+ is a great option if you’re dealing with acne, signs of aging, or both. With three strengths available, it works for a wide range of skin types and tolerance levels, and it’s a great fit if you’re looking to level up and simplify your routine with prescription-strength skincare.

Most patients who are new to retinoids or have sensitive skin start at 0.025% and build up as their skin adjusts. Normal to combination skin usually does well at 0.05%, and if your skin is more resilient or you’ve used tretinoin before, 0.1% is the strongest option.

You’ll pick one at checkout, but your physician reviews your history first and can guide you if a different strength makes more sense.

TretPeptide+ is named for its two main actives: Tretinoin and a Peptide Stack, formulated together by our founding dermatologists. A standard tretinoin prescription gives you just the Tretinoin. TretPeptide+ builds on that with the Peptide Stack for added anti-aging support, plus Ceramides, Niacinamide, and Squalane to keep your barrier strong and skin hydrated along the way.

All three are prescription retinoids, but we have formulated each to address a unique combination of concerns:

TretPeptide+ pairs Tretinoin with a Peptide Stack, so you get acne care and supercharged anti-aging support together
ClariFade pairs Tretinoin with Azelaic Acid, best if you’re also dealing with acne, redness, or dark spots
Sensi-Taz uses stronger, faster-acting Tazarotene, a good option if you’ve used a retinoid before and want more potency

Not sure? Take our skin quiz for a personalized recommendation, or pick whichever matches your goals. Your physician will confirm the right fit for you during your consult.

Most patients start noticing fewer breakouts and smoother-looking skin within 4 to 6 weeks. Improvement in fine lines and texture can start to show around 2 to 3 months, with the most significant anti-aging changes building over 6 to 12 months of consistent use. Dryness, flaking, or a few extra breakouts may occur in the first 2 to 4 weeks. That’s just your skin adjusting and accelerating cell turnover, not a sign it’s not working.

Tretinoin shouldn’t be used during pregnancy, and it isn’t recommended while breastfeeding, so let your provider know if either applies. If you’re already using another retinoid or a strong exfoliating active, mention that too. They’ll help you figure out whether to switch, pause the other product, or work it into your routine safely.

Yes, all three strengths (0.025%, 0.05%, 0.1%) are priced the same, which includes your prescription treatment, physician consultation, and ongoing care, including unlimited messaging with your doctor for questions, follow-ups, or treatment adjustments. You can also adjust your delivery frequency, pause, or cancel anytime.

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TretPeptide+